Bystander effect cells
WebAug 13, 2024 · To explore cystine effect on bystander uptake, cells were incubated with Ag-647 and T-Ag in AA-free medium plus 0.4 mM cystine or 0.4 mM glutathione for 1 h. Cells were also incubated with only T ... WebJul 9, 2015 · INTRODUCTION. Cells traversed by direct irradiation can be affected biologically; non-traversed adjacent cells are also affected by a biological response called the radiation-induced bystander effect (RIBE) [].This response is generated through gap junction intercellular communication (GJIC) between the target and adjacent cells by …
Bystander effect cells
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WebJun 25, 2024 · In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded … WebFeb 9, 2012 · Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo. Cellular senescence is a state of irreversible cell cycle arrest, typically driven by a persistent DNA damage response (DDR) (Campisi & d’Adda di Fagagna, 2007).
WebMar 17, 2024 · The cytotoxic payload may kill cancer cells as a result of DNA damage. Cancer cells may also be inhibited by microtubule disrupting agents. Some membrane permeable payloads (e.g., SN-38) can cross the cell membrane and exert a cytotoxic killing effect on bystander cancer cells, which may or may not express target antigens [2,6]. WebDec 1, 2024 · However, the effect of these therapies on bystander activation of T cells will require in-depth examination to provide insight into developing improved anticancer …
WebMay 9, 2024 · Treating cells and observing the behavior of adjacent cells have been the general methods used to dissect the mechanism of the bystander effect. However, researching the bystander killing effect at the single-cell level is a more recent trend that can uncover biological signals without the influence of uncertain elements associated … WebActivation occurs due to a combination of an inflammatory milieu, co-signaling ligands, and interactions with neighboring cells. In this review, we will discuss the studies …
Web12 rows · A bystander effect occurs when nontransduced or genetically unmodified cells are killed during ...
WebThe radiation-induced bystander effect ( bystander effect) is the phenomenon in which unirradiated cells exhibit irradiated effects as a result of signals received from nearby … deborah beeler murder californiaWebMeanwhile, we further analyzed the effect of suicide gene on the bystander effect of HT29-DF cells over time. The results showed that the proliferation of HT29-DF cells was inhibited as the GCV treatment time increased compared with the control (treated with PBS) group . Effects of MSCs-DF on tumor growth deborah bertholdWebOct 3, 2005 · The mechanism of the radiation-induced bystander effect, whether involving cell–cell contact or mediated by soluble factors, is not clear, is likely to be complex, and involves multiple pathways. It is, however, clear that p53 gene function is not necessary for the effect, because cells without normal p53 function (such as Chinese hamster ... fear street first movieWebDec 11, 2024 · During viral infections, significant numbers of T cells are activated in a T cell receptor-independent and cytokine-dependent manner, a phenomenon referred to as “bystander activation.” deborah berini penn state healthWebJun 17, 2024 · The hematopoietic system is the most sensitive to irradiation, and irradiation leads to acute hematopoietic damage by inducing cell death of all the hematopoietic tissues. 17-20 To explore the mechanisms underlying the impaired long-term engraftment of bystander hematopoietic cells , we first examined the cell-cycle status of bystander … déborah berthetWebThe bystander effect refers to the induction of biological effects in cells that are not directly traversed by a charged particle. The data available concerning the bystander effect fall into two quite separate categories, and it is not certain that the two groups of experiments are addressing the same phenomenon. fear street maya hawkeWebA bystander effect occurs when nontransduced or genetically unmodified cells are killed during death of transduced tumor cells [12] (Figure 6.2).This phenomenon was first suggested by Moolten and later elucidated by Culver et al [13,14].The bystander effect plays a crucial role in tumor regression because even under the best conditions, … fear street music list