Epha2 phosphorylation
WebEphA2, a member of the Eph receptor tyrosine kinases, is frequently overexpressed in a variety of malignancies, including glioblastoma, and its expression is correlated with poor prognosis. EphA2 acts as a tumor promoter through a ligand ephrin-independent mechanism, which requires phosphorylation o … WebEPHA2. A gene on chromosome 1q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound …
Epha2 phosphorylation
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WebProgranulin evoked Akt- and Erk1/2-mediated EphA2 phosphorylation at Ser897, which could drive bladder tumorigenesis. We discovered that EphA2 depletion severely blunted progranulin-dependent motility and anchorage-independent growth, and sensitized bladder cancer cells to cisplatin treatment. WebAug 18, 2024 · Under normal conditions, cell–cell contacts allow EphA2 to interact with ephrin A1, which induces EphA2 phosphorylation and activates its downstream signaling. Tyrosine phosphorylation of EphA2 promotes the generation of a complex …
WebAug 17, 2024 · Our previous study has demonstrated that fatty acid β-oxidation and oxidative phosphorylation (OXPHOS) in mitochondria is an important energy source for establishment of polarity in hepatocytes, and lipid droplets are likely a crucial endogenous resource in providing fatty acids. ... Hepatocyte EphA2 signaling is important for the … WebMar 12, 2024 · EphA2 activates cytoplasmic tyrosine phosphatase leading to auto-phosphorylation and tyrosine phosphorylation of a large number of downstream intracellular substrate protein molecules and...
WebWe show that the ephrin receptor tyrosine kinase A2 (EphA2) is a cellular receptor for KSHV gH-gL. EphA2 co-precipitated with both gH-gL and KSHV virions. Infection of human epithelial cells with a GFP-expressing recombinant KSHV strain, as measured by FACS analysis, was increased upon overexpression of EphA2. WebDec 2, 2024 · Surprisingly, EphA2 S897E, with mutation of the functionally best characterized linker phosphorylation site, shows the weakest HDX differences in these regions (Fig. 5e), suggesting that ...
WebJul 12, 2024 · Although EPHA2 can inhibit tumorigenesis in a ligand-dependent fashion via phosphorylation of Y588 and Y772, it can promote tumorigenesis in a ligand-independent manner via phosphorylation of S897.
WebExogenous ephrin-A1 (an EPHA2 ligand) exacerbated OGD/R-induced EPHA2 phosphorylation at S897, facilitated ZO-1/claudin-5 loss, and promoted BBB leakage in vitro, which were significantly attenuated after stigmasterol treatment. The rat MCAO model confirmed these protective effects in vivo. great falls outlawsWebJul 1, 2009 · EphA2 is a representative member of a 16 member superfamily of receptor tyrosine kinases (RTK). The corresponding ligands for Eph RTKs, called ephrins, are anchored on the plasma membrane through either a glycophosphatidylinositol linkage (ephrin-A) or through a transmembrane domain (ephrin-B). great falls outlaws baseballWebApr 20, 2024 · In T47D EphA2 cells, EA5 binding to EphA2 can block E2-mediated phosphorylation of FAKY925, thereby increasing the sensitivity of the ER to tamoxifen (Gökmen-Polar et al., 2011) (Fig. 2). Trastuzumab is the primary treatment for HER2 + breast cancer patients. EphA2 also causes natural and acquired resistance. flip xt2 pushchairWebJan 22, 2024 · It has been known that EphA2 is phosphorylated at Tyr588, which is triggered by the ligand binding, and at Ser897 downstream of growth factor signaling. Upon mitotic entry, EphA2 is phosphorylated at … great falls pacific steelWebNov 3, 2024 · EphA2 interacts with PLCγ1 and the kinase activity of EphA2 was required for phosphorylation of PLCγ1. In human lung cancer cells, genetic or pharmacologic inhibition of EphA2 decreased phosphorylation of PLCγ1 and loss of … flip xt2 compact folding pushchair reviewsWebApr 6, 2024 · Using western blot, we validated that phosphorylation of JUN at Serine 63 as well as total protein levels of JUN and EPHA2 were reduced upon ponatinib treatment (Supplementary Fig. 8a). flip xt2 pushchair reviewWebJan 22, 2024 · It has been known that EphA2 is phosphorylated at Tyr588, which is triggered by the ligand binding, and at Ser897 downstream of growth factor signaling. Upon mitotic entry, EphA2 is phosphorylated at Ser897, accompanied by a reduction in Tyr588 phosphorylation. flip xt2 review