WebKEY TERMS. T-2 and HT-2 toxin: naturally occurring moulds of fusarium fungus, found in certain grains, with toxic effects on both human and animal health. Fusarium fungi are common toxin-producing fungi and are commonly found on cereals grown in the temperate regions of Europe, America and Asia. Indicative level: these are not feed or food ...
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WebDec 17, 2024 · T-2 toxin is a trichothecene mycotoxin commonly found in animal feed and agricultural products. Evidence indicates that T-2 toxin induces apoptosis and autophagy. … WebOne of the most potent is T-2 toxin, which produces necrotic degeneration of the gastrointestinal tract, and also inhibits leucocyte production, thus acting as an immunosuppressor. The oral LD 50 for T-2 toxin in rats is 5.2 mg kg −1. In chicks, the oral LD 50 is 5.0 mg kg −1 for T-2 toxin, and 7.2 mg kg −1 for the related HT-2 toxin ...
WebDescription. No. of tests/amount. Art. No. RIDASCREEN® T-2 / HT-2 Toxin. RIDASCREEN® T-2 / HT-2 Toxin is a competitive enzyme immunoassay for the quantitative analysis of the sum of T-2 and HT-2 toxin in oats, corn (maize), barley and wheat. Lee más. Microtiter plate with 96 wells (12 strips with 8 wells each) R3805. WebWith over 35 years of experience in this field, Romer Labs offers the most comprehensive portfolio of mycotoxin test kits for the detection of regulated mycotoxins ( aflatoxin, ochratoxin, fumonisin, deoxynivalenol, zearalenone, t-2 and ht-2) in agricultural commodities such as raw grains and nuts, grain by-products and feed formulations.
WebOct 26, 2024 · T-2 mycotoxin is the only mycotoxin known to have been used as a biological weapon. In the event of aerosol exposure, first responders should wear personal protective equipment and evacuate the adjacent area. Decontamination and use of protective clothing are vital, as human-to-human transmission may occur via skin contact. WebT-2 toxin and deoxynivalenol (Figure 4) belong to a large group of structurally-related sesquiterpenes known as the ´trichothecenes'. T-2 toxin is produced on cereals in many parts of the world and is particularly associated with prolonged wet weather at harvest. It is the probable cause of ´alimentary toxic aleukia' (ATA), a disease (IARC ...
WebAug 16, 2024 · T-2 Toxin (T-2) T-2 toxin is a very potent Fusarium-produced mycotoxin that occurs in a low proportion of feed samples (<10%). Russell et al. (1991) found 13% of midwestern corn grain contaminated with T-2 toxin in a survey of the 1988 drought-damaged crop. Effects of T-2 are less well established in cattle than in laboratory animals.
WebBiochem/physiol Actions. The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10 ... toto sh680ba 部品WebT-2 Toxin C24H34O9 CID 442400 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. National Institutes of Health. National Library of Medicine. National Center for Biotechnology Information. PubChem ... toto share priceWebthe T-2 toxin production after growing on rice substrate followed by using specific “Multisep 225 Trich Clean up columns” purification. In this study, T-2 toxin produc-tion was ranged from 197.05ug/kg to 8503.07ug/kg. This is the first study of T-2 toxin analysis by HPLC-F in Iran. Keywords: Fusarium, Trichothecene, T-2 toxin, HPLC-F 1. toto sh681ba 展開図Webt-2毒素是毒性最强、最常见的单端孢霉毒素之一，可引起多种心血管疾病。在这篇综述中，我们总结了当前与 t-2 毒素相关的心脏毒性相关的知识库和挑战。还讨论了分子机制和潜在的治疗方法。病理上，t-2毒素引起的心脏毒性表现为心肌细胞损伤和死亡、毛细血管通透性增加、心肌细胞坏死、出血 ... poteet texas mayorWebT-2 mycotoxin C24H34O9 CID 6711181 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... toto sh681ba 部品Webtreated with 100 mL T-2 toxin at a concentration of LC50, and cultivated for 6, 12, 18, 24 h respectively. Following steps referred to the methods mentioned in MTT assay kit and GSH detection and assay kit. Detection of Caspase-3, 8, 9, p53, and JunD by Western-blot Analysis Cellular cultivation and T-2 toxin treatment was the same to that ... toto shareT-2 mycotoxin has an LD 50 of approximately 1 milligram per kilogram of body weight. The EFSA estimates that the mean exposure of T-2 in the EU lies between 12 and 43 ng/kg bw/day. This range is below the TDI of 100 ng/ kg body weight for the sum of HT-2 and T-2 toxins which is used by the EFSA. Distribution See more T-2 Mycotoxin (pronounced as 'Tee-Two') is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and animals. The clinical condition it causes is See more This compound has a tetracyclic sesquiterpenoid 12,13-epoxytrichothene ring system, which relates it to the trichothecenes. These compounds are generally very stable … See more T-2 mycotoxin is produced naturally by Fusarium fungi of which the most important species are: F. sporotrichioides, F. langsethiae, F. … See more ADME Properties Absorption & Exposure Humans and animals are generally exposed to T-2 mycotoxins through food. Certain grains can contain the toxin which makes it a threat to human health and an economic burden. … See more Alimentary toxic aleukia (ATA), a disease which is caused by trichothecenes like T-2 mycotoxin, killed many thousands of USSR citizens in the Orenburg District in the 1940s. It was reported that the mortality rate was 10% of the entire population in that area. During the … See more The toxicity of T-2 toxin is due to its 12,13-epoxy ring. Epoxides are in general toxic compounds; these react with nucleophiles and then undergo further enzymatic reactions. The reactivity of epoxides can lead to reactions with endogenous compounds and … See more At the moment, there is no specific therapy for T-2 mycotoxin poisonings. Exposure of the mycotoxin is typically followed by standardized treatment for toxic compounds in order to reduce the effect of the toxin. This includes using activated charcoal, … See more toto sh680ba部品